Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages
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چکیده
منابع مشابه
Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages.
The recognition of mycobacterial cell wall components causes macrophages to secrete tumor necrosis factor alpha (TNF-alpha) and other cytokines that are essential for the development of a protective inflammatory response. We show that toll-like receptors are required for the induction of TNF-alpha in macrophages by Mycobacterium tuberculosis. Expression of a dominant negative form of MyD88 (a s...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1999
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.96.25.14459